Drug interactions
Lovastatin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Contraindicated
Lovastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The ritonavir-boosted paritaprevir regimen strongly inhibits CYP3A4 and increases lovastatin concentrations. The risk of myopathy and rhabdomyolysis is high and the combination is contraindicated.
What this interaction means in plain words
Lovastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 by ritonavir and paritaprevir reduces lovastatin metabolism.
What to do
Do not coadminister; stop lovastatin during the antiviral course or use a statin such as pravastatin or rosuvastatin with dose limits. Monitor for muscle symptoms.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Lovastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The ritonavir-boosted paritaprevir regimen strongly inhibits CYP3A4 and increases lovastatin concentrations. The risk of myopathy and rhabdomyolysis is high and the combination is contraindicated.
How serious is the interaction between Lovastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; stop lovastatin during the antiviral course or use a statin such as pravastatin or rosuvastatin with dose limits. Monitor for muscle symptoms.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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