Drug interactions
Lovastatin + Pentobarbital
Severity: Moderate
Lovastatin and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and can lower lovastatin plasma concentrations. This may reduce lipid-lowering efficacy.
What this interaction means in plain words
Lovastatin and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic and intestinal CYP3A4 increases lovastatin clearance.
What to do
Monitor lipid profile and increase the statin dose or switch to a statin not metabolized by CYP3A4 if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Pentobarbital?
MediHelp rates the interaction as moderate. Lovastatin and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and can lower lovastatin plasma concentrations. This may reduce lipid-lowering efficacy.
How serious is the interaction between Lovastatin and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid profile and increase the statin dose or switch to a statin not metabolized by CYP3A4 if control is inadequate.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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