Drug interactions
Lovastatin + Ponatinib
Severity: Moderate
Lovastatin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-gp and BCRP and may increase lovastatin exposure. Ponatinib itself can cause hepatotoxicity and muscle toxicity, so combined statin-related adverse effects are a concern.
What this interaction means in plain words
Lovastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits P-glycoprotein and BCRP, increasing lovastatin absorption.
What to do
Monitor for myalgia, CK elevation and liver enzymes, and lower the lovastatin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Lovastatin with Ponatinib?
MediHelp rates the interaction as moderate. Lovastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-gp and BCRP and may increase lovastatin exposure. Ponatinib itself can cause hepatotoxicity and muscle toxicity, so combined statin-related adverse effects are a concern.
How serious is the interaction between Lovastatin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia, CK elevation and liver enzymes, and lower the lovastatin dose if toxicity appears.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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