Drug interactions
Loxapine + Morphine
Severity: Moderate
Loxapine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine can add to morphine's sedation, hypotension and respiratory depression. Inhaled loxapine carries a bronchospasm warning that may be relevant to patients with airway disease.
What this interaction means in plain words
Loxapine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic receptor blockade.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose if oversedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Morphine?
MediHelp rates the interaction as moderate. Loxapine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine can add to morphine's sedation, hypotension and respiratory depression. Inhaled loxapine carries a bronchospasm warning that may be relevant to patients with airway disease.
How serious is the interaction between Loxapine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Reduce the opioid dose if oversedation develops.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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