Drug interactions
Loxapine + Phenelzine
Severity: Moderate
Loxapine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine with an MAOI may cause additive hypotension and sedation, and rarely neuroleptic malignant syndrome or serotonin syndrome. Loxapine has serotonin receptor antagonist activity in addition to dopamine blockade.
What this interaction means in plain words
Loxapine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: dopamine D2 and serotonin receptor blockade combined with the increased monoamine levels and hypotensive action of MAO inhibition.
What to do
Monitor blood pressure and for fever, rigidity, clonus and altered mental status, especially after initiation or dose increases. Stop one agent if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Phenelzine?
MediHelp rates the interaction as moderate. Loxapine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine with an MAOI may cause additive hypotension and sedation, and rarely neuroleptic malignant syndrome or serotonin syndrome. Loxapine has serotonin receptor antagonist activity in addition to dopamine blockade.
How serious is the interaction between Loxapine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for fever, rigidity, clonus and altered mental status, especially after initiation or dose increases. Stop one agent if toxicity is suspected.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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