Drug interactions
Loxapine + Primidone
Severity: Moderate
Loxapine and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly metabolized to phenobarbital, adds to the sedative effects of loxapine and may increase drowsiness and impair coordination. Loxapine can also lower the seizure threshold, potentially reducing seizure control in epilepsy.
What this interaction means in plain words
Loxapine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with enzyme induction by primidone and its phenobarbital metabolite possibly lowering loxapine levels.
What to do
Monitor sedation and seizure control, and adjust doses as needed. Reassess loxapine efficacy after primidone is started or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Loxapine with Primidone?
MediHelp rates the interaction as moderate. Loxapine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly metabolized to phenobarbital, adds to the sedative effects of loxapine and may increase drowsiness and impair coordination. Loxapine can also lower the seizure threshold, potentially reducing seizure control in epilepsy.
How serious is the interaction between Loxapine and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure control, and adjust doses as needed. Reassess loxapine efficacy after primidone is started or changed.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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