Drug interactions
Loxapine + Salmeterol
Severity: Minor
Loxapine and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect the heart: salmeterol is a beta-2 agonist that may prolong QT interval and cause tachycardia, and loxapine is an antipsychotic with potential QT-prolonging and orthostatic effects. Combined use could add to the risk of palpitations or arrhythmia in susceptible patients.
What this interaction means in plain words
Loxapine and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loxapine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Possible additive cardiac effects (QT prolongation and heart rate changes) through different pharmacodynamic pathways.
What to do
Be aware in patients with cardiac disease or other QT-prolonging drugs and consider an ECG and electrolyte check if palpitations or syncope occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Salmeterol?
MediHelp rates the interaction as minor. Loxapine and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can affect the heart: salmeterol is a beta-2 agonist that may prolong QT interval and cause tachycardia, and loxapine is an antipsychotic with potential QT-prolonging and orthostatic effects. Combined use could add to the risk of palpitations or arrhythmia in susceptible patients.
How serious is the interaction between Loxapine and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware in patients with cardiac disease or other QT-prolonging drugs and consider an ECG and electrolyte check if palpitations or syncope occur.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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