Drug interactions
Loxapine + Selegiline
Severity: Moderate
Loxapine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a dopamine-enhancing MAO-B inhibitor, so it opposes the dopamine blockade of loxapine and may worsen psychosis or reduce selegiline's effect in Parkinson disease. At higher doses selegiline loses selectivity, and serotonergic toxicity or hypotension may occur.
What this interaction means in plain words
Loxapine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine agonism and D2 blockade, plus possible nonselective MAO inhibition at higher selegiline doses.
What to do
Monitor motor symptoms, psychiatric status, and blood pressure, and keep selegiline at recommended doses. For Parkinson disease patients, prefer an antipsychotic with less D2 blockade such as quetiapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Loxapine with Selegiline?
MediHelp rates the interaction as moderate. Loxapine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is a dopamine-enhancing MAO-B inhibitor, so it opposes the dopamine blockade of loxapine and may worsen psychosis or reduce selegiline's effect in Parkinson disease. At higher doses selegiline loses selectivity, and serotonergic toxicity or hypotension may occur.
How serious is the interaction between Loxapine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms, psychiatric status, and blood pressure, and keep selegiline at recommended doses. For Parkinson disease patients, prefer an antipsychotic with less D2 blockade such as quetiapine.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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