Drug interactions
Loxapine + Tolterodine
Severity: Moderate
Loxapine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has antimuscarinic activity, so combining it with tolterodine increases anticholinergic burden. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion. Both drugs may also affect QT interval.
What this interaction means in plain words
Loxapine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and possible additive QT prolongation.
What to do
Monitor for anticholinergic toxicity and consider an ECG if QT risk factors are present. Use the lowest effective doses, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Tolterodine?
MediHelp rates the interaction as moderate. Loxapine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has antimuscarinic activity, so combining it with tolterodine increases anticholinergic burden. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion. Both drugs may also affect QT interval.
How serious is the interaction between Loxapine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider an ECG if QT risk factors are present. Use the lowest effective doses, especially in older patients.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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