Drug interactions
Loxapine inhaled + Lurasidone
Severity: Moderate
Loxapine inhaled and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antipsychotics with sedative properties, so combined use can increase drowsiness and cognitive impairment. Inhaled loxapine also carries a risk of bronchospasm, and additive extrapyramidal effects and orthostatic hypotension are possible.
What this interaction means in plain words
Loxapine inhaled and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and dopamine-blocking effects of two antipsychotics.
What to do
Monitor for oversedation, extrapyramidal symptoms and hypotension after each inhaled loxapine dose. Make sure the inhaled loxapine REMS precautions are followed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Lurasidone?
MediHelp rates the interaction as moderate. Loxapine inhaled and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antipsychotics with sedative properties, so combined use can increase drowsiness and cognitive impairment. Inhaled loxapine also carries a risk of bronchospasm, and additive extrapyramidal effects and orthostatic hypotension are possible.
How serious is the interaction between Loxapine inhaled and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, extrapyramidal symptoms and hypotension after each inhaled loxapine dose. Make sure the inhaled loxapine REMS precautions are followed.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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