Drug interactions
Loxapine inhaled + Meperidine
Severity: Moderate
Loxapine inhaled and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is sedating and inhaled loxapine can cause bronchospasm and CNS depression, which may add to opioid effects. Meperidine's serotonergic activity and antipsychotic dopamine blockade also create a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Loxapine inhaled and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with a possible serotonergic and dopaminergic contribution.
What to do
Monitor sedation, respiratory status and signs of serotonin toxicity or neuroleptic malignant syndrome. Reduce opioid dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Meperidine?
MediHelp rates the interaction as moderate. Loxapine inhaled and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine is sedating and inhaled loxapine can cause bronchospasm and CNS depression, which may add to opioid effects. Meperidine's serotonergic activity and antipsychotic dopamine blockade also create a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Loxapine inhaled and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory status and signs of serotonin toxicity or neuroleptic malignant syndrome. Reduce opioid dose if excessive sedation occurs.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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