Drug interactions
Loxapine inhaled + Midazolam
Severity: Moderate
Loxapine inhaled and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use increases sedation and drowsiness. Inhaled loxapine can also cause bronchospasm, which is more hazardous in a patient who is heavily sedated.
What this interaction means in plain words
Loxapine inhaled and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation by midazolam and antipsychotic sedative effects of loxapine.
What to do
Use the lowest effective midazolam dose and monitor sedation level, respiratory rate and oxygen saturation. Have bronchodilator and airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Midazolam?
MediHelp rates the interaction as moderate. Loxapine inhaled and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use increases sedation and drowsiness. Inhaled loxapine can also cause bronchospasm, which is more hazardous in a patient who is heavily sedated.
How serious is the interaction between Loxapine inhaled and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor sedation level, respiratory rate and oxygen saturation. Have bronchodilator and airway support available.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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