Drug interactions
Loxapine inhaled + Nabilone
Severity: Moderate
Loxapine inhaled and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taken together they can deepen drowsiness and impair alertness and psychomotor performance. Inhaled loxapine can also cause bronchospasm and sedation, so added sedation is more concerning in a monitored setting.
What this interaction means in plain words
Loxapine inhaled and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from a cannabinoid and an antipsychotic.
What to do
Monitor the level of sedation and respiratory status after loxapine administration, and advise the patient against driving or operating machinery. Consider reducing the nabilone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Loxapine inhaled with Nabilone?
MediHelp rates the interaction as moderate. Loxapine inhaled and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taken together they can deepen drowsiness and impair alertness and psychomotor performance. Inhaled loxapine can also cause bronchospasm and sedation, so added sedation is more concerning in a monitored setting.
How serious is the interaction between Loxapine inhaled and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the level of sedation and respiratory status after loxapine administration, and advise the patient against driving or operating machinery. Consider reducing the nabilone dose if excessive sedation occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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