Drug interactions
Lumacaftor / ivacaftor + Midazolam
Severity: Moderate
Lumacaftor / ivacaftor and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and can substantially reduce midazolam concentrations, particularly oral doses, causing loss of sedative effect.
What this interaction means in plain words
Lumacaftor / ivacaftor and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4, increasing midazolam metabolism.
What to do
Monitor clinical response and titrate midazolam upward as needed. Consider alternatives less dependent on CYP3A4 metabolism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Midazolam?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and can substantially reduce midazolam concentrations, particularly oral doses, causing loss of sedative effect.
How serious is the interaction between Lumacaftor / ivacaftor and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and titrate midazolam upward as needed. Consider alternatives less dependent on CYP3A4 metabolism.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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