Drug interactions
Lumacaftor / ivacaftor + Omeprazole
Severity: Moderate
Lumacaftor / ivacaftor and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4, which may reduce omeprazole exposure and acid suppression. Net effect varies.
What this interaction means in plain words
Lumacaftor / ivacaftor and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induction of CYP2C19 and CYP3A4 increases omeprazole clearance.
What to do
Monitor symptom control and increase the omeprazole dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Omeprazole?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4, which may reduce omeprazole exposure and acid suppression. Net effect varies.
How serious is the interaction between Lumacaftor / ivacaftor and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and increase the omeprazole dose if needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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