Drug interactions
Lumacaftor / ivacaftor + Rimegepant
Severity: Moderate
Lumacaftor / ivacaftor and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and can lower rimegepant concentrations. This may lead to loss of efficacy.
What this interaction means in plain words
Lumacaftor / ivacaftor and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by lumacaftor, increasing rimegepant metabolism.
What to do
Avoid concomitant use and choose another acute migraine treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Rimegepant?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and can lower rimegepant concentrations. This may lead to loss of efficacy.
How serious is the interaction between Lumacaftor / ivacaftor and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose another acute migraine treatment.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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