Drug interactions
Lumacaftor / ivacaftor + Voriconazole
Severity: Moderate
Lumacaftor / ivacaftor and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole, a strong CYP3A inhibitor, raises ivacaftor exposure. Lumacaftor induces CYP3A, which offsets this effect at steady state, so the net change is limited. Problems are mainly relevant when voriconazole is started or stopped, and lumacaftor/ivacaftor can in turn lower voriconazole levels.
What this interaction means in plain words
Lumacaftor / ivacaftor and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of ivacaftor, while lumacaftor induces CYP3A and may reduce voriconazole concentrations.
What to do
No lumacaftor/ivacaftor dose change is needed when voriconazole is added to established therapy. Monitor for ivacaftor adverse effects and for loss of antifungal efficacy, using voriconazole trough levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Voriconazole?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole, a strong CYP3A inhibitor, raises ivacaftor exposure. Lumacaftor induces CYP3A, which offsets this effect at steady state, so the net change is limited. Problems are mainly relevant when voriconazole is started or stopped, and lumacaftor/ivacaftor can in turn lower voriconazole levels.
How serious is the interaction between Lumacaftor / ivacaftor and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No lumacaftor/ivacaftor dose change is needed when voriconazole is added to established therapy. Monitor for ivacaftor adverse effects and for loss of antifungal efficacy, using voriconazole trough levels if available.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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