Drug interactions
Lumateperone + Mifepristone
Severity: Major
Lumateperone and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can increase lumateperone exposure by inhibiting CYP3A4. This may increase sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Lumateperone and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lumateperone belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated lumateperone metabolism by mifepristone.
What to do
Reduce lumateperone to 10.5 mg daily during use of a strong CYP3A4 inhibitor. Monitor for sedation and blood pressure changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Lumateperone with Mifepristone?
MediHelp rates the interaction as major. Lumateperone and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone can increase lumateperone exposure by inhibiting CYP3A4. This may increase sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Lumateperone and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 10.5 mg daily during use of a strong CYP3A4 inhibitor. Monitor for sedation and blood pressure changes.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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