Drug interactions
Lumateperone + Verapamil
Severity: Moderate
Lumateperone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil increases lumateperone exposure by inhibiting CYP3A4. This may increase sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Lumateperone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lumateperone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition decreases lumateperone clearance.
What to do
Reduce lumateperone to 21 mg daily during co-administration, and monitor for sedation and orthostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Lumateperone with Verapamil?
MediHelp rates the interaction as moderate. Lumateperone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil increases lumateperone exposure by inhibiting CYP3A4. This may increase sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Lumateperone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily during co-administration, and monitor for sedation and orthostasis.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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