Drug interactions
Lumefantrine + Metoprolol
Severity: Moderate
Lumefantrine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and may raise metoprolol exposure, increasing bradycardia and hypotension. Lumefantrine also affects QT, adding to cardiac concern.
What this interaction means in plain words
Lumefantrine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by lumefantrine.
What to do
Monitor heart rate and blood pressure and reduce the metoprolol dose if bradycardia or hypotension occurs. Consider an ECG during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Lumefantrine with Metoprolol?
MediHelp rates the interaction as moderate. Lumefantrine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6 and may raise metoprolol exposure, increasing bradycardia and hypotension. Lumefantrine also affects QT, adding to cardiac concern.
How serious is the interaction between Lumefantrine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the metoprolol dose if bradycardia or hypotension occurs. Consider an ECG during treatment.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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