Drug interactions
Lumefantrine + Midazolam
Severity: Minor
Lumefantrine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine may modestly lower midazolam exposure, which could reduce sedative effect. The magnitude is small and is unlikely to matter for most patients.
What this interaction means in plain words
Lumefantrine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of CYP3A4 by lumefantrine, increasing midazolam metabolism.
What to do
No dose change is routinely needed; titrate midazolam to clinical sedation effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Lumefantrine with Midazolam?
MediHelp rates the interaction as minor. Lumefantrine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine may modestly lower midazolam exposure, which could reduce sedative effect. The magnitude is small and is unlikely to matter for most patients.
How serious is the interaction between Lumefantrine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; titrate midazolam to clinical sedation effect.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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