Drug interactions
Lumefantrine + Ribociclib
Severity: Major
Lumefantrine and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and ribociclib may raise lumefantrine levels through CYP3A4 inhibition. This increases the risk of QT-related arrhythmias.
What this interaction means in plain words
Lumefantrine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation plus ribociclib inhibition of CYP3A4 metabolism of lumefantrine.
What to do
Avoid if feasible; treat malaria with a non-QT-prolonging option if available. If needed, obtain ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Lumefantrine with Ribociclib?
MediHelp rates the interaction as major. Lumefantrine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, and ribociclib may raise lumefantrine levels through CYP3A4 inhibition. This increases the risk of QT-related arrhythmias.
How serious is the interaction between Lumefantrine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible; treat malaria with a non-QT-prolonging option if available. If needed, obtain ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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