Drug interactions
Lumefantrine + Sirolimus
Severity: Minor
Lumefantrine and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy direction suggests lumefantrine lowers sirolimus, but lumefantrine is a weak CYP3A4 substrate with no established inducing effect on sirolimus. A clinically meaningful interaction is not well documented.
What this interaction means in plain words
Lumefantrine and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; any effect on CYP3A4 is uncertain.
What to do
Monitor sirolimus trough concentrations if artemether-lumefantrine is given during transplant therapy, and adjust the dose only if levels change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Lumefantrine with Sirolimus?
MediHelp rates the interaction as minor. Lumefantrine and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy direction suggests lumefantrine lowers sirolimus, but lumefantrine is a weak CYP3A4 substrate with no established inducing effect on sirolimus. A clinically meaningful interaction is not well documented.
How serious is the interaction between Lumefantrine and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations if artemether-lumefantrine is given during transplant therapy, and adjust the dose only if levels change.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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