Drug interactions
Lumefantrine + Solifenacin
Severity: Moderate
Lumefantrine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a weak CYP3A4 inhibitor in vitro and not an established inducer, so any effect on solifenacin is uncertain. Both drugs can prolong the QT interval, which is the more relevant concern.
What this interaction means in plain words
Lumefantrine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT-interval prolongation; any effect on CYP3A4 metabolism of solifenacin is not well established.
What to do
Check an ECG and electrolytes if both are used in patients with QT risk factors, and consider an alternative to solifenacin during antimalarial treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Lumefantrine with Solifenacin?
MediHelp rates the interaction as moderate. Lumefantrine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a weak CYP3A4 inhibitor in vitro and not an established inducer, so any effect on solifenacin is uncertain. Both drugs can prolong the QT interval, which is the more relevant concern.
How serious is the interaction between Lumefantrine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes if both are used in patients with QT risk factors, and consider an alternative to solifenacin during antimalarial treatment.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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