Drug interactions
Lumefantrine + Voriconazole
Severity: Major
Lumefantrine and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise lumefantrine concentrations, and both drugs can prolong the QT interval. Together they increase the risk of QT prolongation and ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Lumefantrine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by voriconazole reduces lumefantrine metabolism, combined with additive QT-prolonging effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG during treatment, or choose an alternative antimalarial or antifungal where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Lumefantrine with Voriconazole?
MediHelp rates the interaction as major. Lumefantrine and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may raise lumefantrine concentrations, and both drugs can prolong the QT interval. Together they increase the risk of QT prolongation and ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Lumefantrine and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG during treatment, or choose an alternative antimalarial or antifungal where possible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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