Drug interactions
Lurasidone + Metformin-sitagliptin
Severity: Moderate
Lurasidone and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone, an atypical antipsychotic, can cause hyperglycemia and metabolic disturbance in some patients. This may offset the glucose-lowering effect of metformin and sitagliptin and worsen diabetes control.
What this interaction means in plain words
Lurasidone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c after starting lurasidone and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Lurasidone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone, an atypical antipsychotic, can cause hyperglycemia and metabolic disturbance in some patients. This may offset the glucose-lowering effect of metformin and sitagliptin and worsen diabetes control.
How serious is the interaction between Lurasidone and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting lurasidone and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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