Drug interactions
Lurasidone + Metformin
Severity: Minor
Lurasidone and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can modestly alter glucose metabolism, though it is among the antipsychotics with lower metabolic liability. This may reduce the glycemic control achieved with metformin in some patients.
What this interaction means in plain words
Lurasidone and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as antipsychotic-related insulin resistance may counteract metformin's glucose-lowering effect.
What to do
Monitor fasting glucose and HbA1c after starting lurasidone in patients taking metformin. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Metformin
Frequently asked questions
Can I take Lurasidone with Metformin?
MediHelp rates the interaction as minor. Lurasidone and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurasidone can modestly alter glucose metabolism, though it is among the antipsychotics with lower metabolic liability. This may reduce the glycemic control achieved with metformin in some patients.
How serious is the interaction between Lurasidone and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting lurasidone in patients taking metformin. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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