Drug interactions
Lurasidone + Methylergonovine
Severity: Minor
Lurasidone and Methylergonovine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is an ergot derivative with serotonergic activity. The combination with lurasidone is not well studied and the legacy serotonin-syndrome concern is largely theoretical. A more relevant issue is that methylergonovine is metabolized by CYP3A4, but lurasidone is not a significant CYP3A4 inhibitor.
What this interaction means in plain words
Lurasidone and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not well established; possible additive serotonergic or vasoactive effects.
What to do
Limit methylergonovine to short courses and monitor for hypertension, agitation or other serotonergic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Methylergonovine?
MediHelp rates the interaction as minor. Lurasidone and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylergonovine is an ergot derivative with serotonergic activity. The combination with lurasidone is not well studied and the legacy serotonin-syndrome concern is largely theoretical. A more relevant issue is that methylergonovine is metabolized by CYP3A4, but lurasidone is not a significant CYP3A4 inhibitor.
How serious is the interaction between Lurasidone and Methylergonovine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit methylergonovine to short courses and monitor for hypertension, agitation or other serotonergic symptoms.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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