Drug interactions
Lurasidone + Metoclopramide intranasal
Severity: Major
Lurasidone and Metoclopramide intranasal: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block central dopamine D2 receptors, so the combination raises the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Metoclopramide labeling recommends avoiding other drugs with this effect.
What this interaction means in plain words
Lurasidone and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive dopamine D2 receptor antagonism.
What to do
Avoid the combination and use an antiemetic or prokinetic without dopamine antagonism. If used, monitor for movement disorders and rigidity or hyperthermia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Metoclopramide intranasal?
MediHelp rates the interaction as major. Lurasidone and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block central dopamine D2 receptors, so the combination raises the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Metoclopramide labeling recommends avoiding other drugs with this effect.
How serious is the interaction between Lurasidone and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic or prokinetic without dopamine antagonism. If used, monitor for movement disorders and rigidity or hyperthermia.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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