Drug interactions
Lurasidone + Midazolam intranasal
Severity: Moderate
Lurasidone and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and intranasal midazolam can cause respiratory depression, so combined use may increase the risk of hypoventilation and prolonged sedation. Lurasidone is not a meaningful CYP3A4 inhibitor, so the legacy pharmacokinetic claim is doubtful.
What this interaction means in plain words
Lurasidone and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Monitor respiratory status and level of consciousness after the midazolam dose, and ensure observation and resuscitation capability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Midazolam intranasal?
MediHelp rates the interaction as moderate. Lurasidone and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and intranasal midazolam can cause respiratory depression, so combined use may increase the risk of hypoventilation and prolonged sedation. Lurasidone is not a meaningful CYP3A4 inhibitor, so the legacy pharmacokinetic claim is doubtful.
How serious is the interaction between Lurasidone and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and level of consciousness after the midazolam dose, and ensure observation and resuscitation capability.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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