Drug interactions
Lurasidone + Nafcillin
Severity: Moderate
Lurasidone and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a weak to moderate inducer of CYP3A4, and lurasidone is cleared mainly by this enzyme. Prolonged co-treatment may lower lurasidone exposure and reduce its antipsychotic effect, with a risk of relapse or loss of symptom control.
What this interaction means in plain words
Lurasidone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of intestinal and hepatic CYP3A4 by nafcillin increases the metabolic clearance of lurasidone.
What to do
Monitor for loss of psychiatric response during and after a course of nafcillin. Consider increasing the lurasidone dose if the combination continues for a week or longer, and reassess the dose when nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Nafcillin?
MediHelp rates the interaction as moderate. Lurasidone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a weak to moderate inducer of CYP3A4, and lurasidone is cleared mainly by this enzyme. Prolonged co-treatment may lower lurasidone exposure and reduce its antipsychotic effect, with a risk of relapse or loss of symptom control.
How serious is the interaction between Lurasidone and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric response during and after a course of nafcillin. Consider increasing the lurasidone dose if the combination continues for a week or longer, and reassess the dose when nafcillin is stopped.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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