Drug interactions
Lurasidone + Nefazodone
Severity: Contraindicated
Lurasidone and Nefazodone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can considerably increase lurasidone exposure. This raises the risk of dose-related adverse effects including sedation and extrapyramidal symptoms. Strong CYP3A4 inhibitors are contraindicated with lurasidone.
What this interaction means in plain words
Lurasidone and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone.
What to do
Avoid the combination; use a different antidepressant that does not strongly inhibit CYP3A4.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Nefazodone?
MediHelp rates the interaction as contraindicated. Lurasidone and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone is a strong CYP3A4 inhibitor and can considerably increase lurasidone exposure. This raises the risk of dose-related adverse effects including sedation and extrapyramidal symptoms. Strong CYP3A4 inhibitors are contraindicated with lurasidone.
How serious is the interaction between Lurasidone and Nefazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antidepressant that does not strongly inhibit CYP3A4.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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