Drug interactions
Lurasidone + Nirmatrelvir
Severity: Contraindicated
Lurasidone and Nirmatrelvir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is a CYP3A4 inhibitor given with ritonavir, and the regimen markedly increases exposure to CYP3A substrates such as lurasidone. This may cause serious dose-related adverse effects including sedation and extrapyramidal symptoms. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Lurasidone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lurasidone belongs to Central Nervous System; Nirmatrelvir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by nirmatrelvir and ritonavir reduces lurasidone clearance.
What to do
Avoid during the treatment course; consider holding lurasidone or using another COVID-19 therapy, with specialist advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Lurasidone with Nirmatrelvir?
MediHelp rates the interaction as contraindicated. Lurasidone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nirmatrelvir is a CYP3A4 inhibitor given with ritonavir, and the regimen markedly increases exposure to CYP3A substrates such as lurasidone. This may cause serious dose-related adverse effects including sedation and extrapyramidal symptoms. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Lurasidone and Nirmatrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during the treatment course; consider holding lurasidone or using another COVID-19 therapy, with specialist advice.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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