Drug interactions
Lurasidone + Olanzapine
Severity: Moderate
Lurasidone and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two antipsychotics together increases the burden of sedation, orthostatic hypotension, extrapyramidal symptoms and metabolic adverse effects. Olanzapine adds substantial weight and glucose risk, and there is little evidence that the combination improves outcomes over monotherapy.
What this interaction means in plain words
Lurasidone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive dopamine and serotonin receptor blockade and additive CNS depression.
What to do
Avoid antipsychotic polypharmacy when possible; if combined, monitor sedation, movement disorders, weight, glucose and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Lurasidone with Olanzapine?
MediHelp rates the interaction as moderate. Lurasidone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two antipsychotics together increases the burden of sedation, orthostatic hypotension, extrapyramidal symptoms and metabolic adverse effects. Olanzapine adds substantial weight and glucose risk, and there is little evidence that the combination improves outcomes over monotherapy.
How serious is the interaction between Lurasidone and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy when possible; if combined, monitor sedation, movement disorders, weight, glucose and lipids.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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