Drug interactions
Lurasidone + Olopatadine intranasal
Severity: Moderate
Lurasidone and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olopatadine nasal spray can cause somnolence, and lurasidone is also sedating. Together they may cause additive drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Lurasidone and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistaminergic and antipsychotic sedation.
What to do
Warn patients about drowsiness and caution against driving until the response is known. Consider a less sedating alternative if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Lurasidone and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olopatadine nasal spray can cause somnolence, and lurasidone is also sedating. Together they may cause additive drowsiness and impaired psychomotor performance.
How serious is the interaction between Lurasidone and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and caution against driving until the response is known. Consider a less sedating alternative if sedation is troublesome.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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