Drug interactions
Lurasidone + Phenobarbital
Severity: Contraindicated
Lurasidone and Phenobarbital: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and can lower lurasidone exposure, risking loss of efficacy and relapse. Additive CNS depression may also occur. Lurasidone labeling contraindicates strong CYP3A4 inducers.
What this interaction means in plain words
Lurasidone and Phenobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Induction of CYP3A4 increases the metabolic clearance of lurasidone.
What to do
Avoid the combination; use a non-inducing anticonvulsant or a different antipsychotic and monitor clinical response.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Phenobarbital?
MediHelp rates the interaction as contraindicated. Lurasidone and Phenobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbital induces CYP3A4 and can lower lurasidone exposure, risking loss of efficacy and relapse. Additive CNS depression may also occur. Lurasidone labeling contraindicates strong CYP3A4 inducers.
How serious is the interaction between Lurasidone and Phenobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-inducing anticonvulsant or a different antipsychotic and monitor clinical response.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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