Drug interactions
Lurasidone + Pimozide
Severity: Major
Lurasidone and Pimozide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide and lurasidone are both antipsychotics with dopamine blocking activity. Combining them increases the risk of extrapyramidal symptoms, sedation, and neuroleptic malignant syndrome, and pimozide's QT prolongation adds to the concern. There is no justification for dual antipsychotic therapy in most patients.
What this interaction means in plain words
Lurasidone and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurasidone belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive D2 receptor antagonism, CNS depression and QT-prolonging potential.
What to do
Avoid concurrent use where possible. If it is unavoidable, check the ECG and electrolytes at baseline and monitor for extrapyramidal symptoms, sedation, and signs of neuroleptic malignant syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Pimozide?
MediHelp rates the interaction as major. Lurasidone and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide and lurasidone are both antipsychotics with dopamine blocking activity. Combining them increases the risk of extrapyramidal symptoms, sedation, and neuroleptic malignant syndrome, and pimozide's QT prolongation adds to the concern. There is no justification for dual antipsychotic therapy in most patients.
How serious is the interaction between Lurasidone and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If it is unavoidable, check the ECG and electrolytes at baseline and monitor for extrapyramidal symptoms, sedation, and signs of neuroleptic malignant syndrome.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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