Drug interactions
Lurasidone + Pindolol
Severity: Moderate
Lurasidone and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone's alpha-1 blockade can cause orthostatic hypotension, adding to the blood pressure lowering effect of pindolol. Dizziness, syncope and falls may result.
What this interaction means in plain words
Lurasidone and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects of alpha-1 blockade and beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Pindolol?
MediHelp rates the interaction as moderate. Lurasidone and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone's alpha-1 blockade can cause orthostatic hypotension, adding to the blood pressure lowering effect of pindolol. Dizziness, syncope and falls may result.
How serious is the interaction between Lurasidone and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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