Drug interactions
Lurasidone + Protriptyline
Severity: Moderate
Lurasidone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the central nervous system and can cause sedation, dizziness and psychomotor slowing. Protriptyline also has anticholinergic and orthostatic effects that may add to those of lurasidone. Combined use can increase the risk of impaired alertness and falls.
What this interaction means in plain words
Lurasidone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system and orthostatic pharmacodynamic effects of an atypical antipsychotic and a tricyclic antidepressant.
What to do
Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects, especially after starting or raising doses. Counsel patients about driving and fall risk and reduce doses if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Protriptyline?
MediHelp rates the interaction as moderate. Lurasidone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on the central nervous system and can cause sedation, dizziness and psychomotor slowing. Protriptyline also has anticholinergic and orthostatic effects that may add to those of lurasidone. Combined use can increase the risk of impaired alertness and falls.
How serious is the interaction between Lurasidone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects, especially after starting or raising doses. Counsel patients about driving and fall risk and reduce doses if adverse effects appear.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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