Drug interactions
Lurasidone + Remifentanil
Severity: Moderate
Lurasidone and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating antipsychotic can increase drowsiness, dizziness and orthostatic hypotension, and may add to respiratory depression. The risk is greatest at higher doses and in frail patients.
What this interaction means in plain words
Lurasidone and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects from opioid agonism and antipsychotic receptor blockade.
What to do
Use the lowest effective remifentanil dose and monitor sedation, blood pressure and respiratory rate. Counsel ambulatory patients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Remifentanil?
MediHelp rates the interaction as moderate. Lurasidone and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a sedating antipsychotic can increase drowsiness, dizziness and orthostatic hypotension, and may add to respiratory depression. The risk is greatest at higher doses and in frail patients.
How serious is the interaction between Lurasidone and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective remifentanil dose and monitor sedation, blood pressure and respiratory rate. Counsel ambulatory patients about impaired alertness.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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