Drug interactions
Lurasidone + Saquinavir
Severity: Contraindicated
Lurasidone and Saquinavir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and is expected to increase lurasidone concentrations markedly. This raises the risk of extrapyramidal symptoms, sedation and other dose-related effects. QT effects of saquinavir add further concern.
What this interaction means in plain words
Lurasidone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone.
What to do
Do not coadminister; use an alternative antipsychotic or antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Saquinavir?
MediHelp rates the interaction as contraindicated. Lurasidone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and is expected to increase lurasidone concentrations markedly. This raises the risk of extrapyramidal symptoms, sedation and other dose-related effects. QT effects of saquinavir add further concern.
How serious is the interaction between Lurasidone and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antipsychotic or antiretroviral regimen.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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