Drug interactions
Lurasidone + Sumatriptan intranasal
Severity: Minor
Lurasidone and Sumatriptan intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic triptan with an antipsychotic has been associated in theory with serotonin syndrome, and altered dopamine blockade could add to neuroleptic malignant syndrome risk. Reports are rare and the risk with intranasal sumatriptan is low.
What this interaction means in plain words
Lurasidone and Sumatriptan intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive serotonergic effects (5-HT1B/1D agonism with 5-HT receptor modulation by lurasidone).
What to do
No routine change is needed, but monitor for agitation, tremor, hyperthermia, rigidity or autonomic instability after starting. Stop the combination if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Sumatriptan intranasal?
MediHelp rates the interaction as minor. Lurasidone and Sumatriptan intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a serotonergic triptan with an antipsychotic has been associated in theory with serotonin syndrome, and altered dopamine blockade could add to neuroleptic malignant syndrome risk. Reports are rare and the risk with intranasal sumatriptan is low.
How serious is the interaction between Lurasidone and Sumatriptan intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed, but monitor for agitation, tremor, hyperthermia, rigidity or autonomic instability after starting. Stop the combination if serotonin toxicity is suspected.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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