Drug interactions
Lurasidone + Telmisartan-amlodipine
Severity: Moderate
Lurasidone and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 adrenergic blocking activity and can cause orthostatic hypotension, which may add to the effect of the antihypertensive combination. Dizziness and falls may result, particularly early in treatment or after dose increases.
What this interaction means in plain words
Lurasidone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism by lurasidone and the vasodilating and angiotensin-blocking actions of the antihypertensives.
What to do
Monitor blood pressure, including standing readings, when starting or titrating lurasidone, and reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Lurasidone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 adrenergic blocking activity and can cause orthostatic hypotension, which may add to the effect of the antihypertensive combination. Dizziness and falls may result, particularly early in treatment or after dose increases.
How serious is the interaction between Lurasidone and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or titrating lurasidone, and reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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