Drug interactions
Lurasidone + Thalidomide
Severity: Moderate
Lurasidone and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide commonly causes somnolence and dizziness, which may be amplified by lurasidone. Patients may experience impaired alertness and increased fall risk.
What this interaction means in plain words
Lurasidone and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and advise against driving or hazardous tasks until response is known. Give thalidomide at bedtime to reduce daytime impact.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Thalidomide
Frequently asked questions
Can I take Lurasidone with Thalidomide?
MediHelp rates the interaction as moderate. Lurasidone and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide commonly causes somnolence and dizziness, which may be amplified by lurasidone. Patients may experience impaired alertness and increased fall risk.
How serious is the interaction between Lurasidone and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise against driving or hazardous tasks until response is known. Give thalidomide at bedtime to reduce daytime impact.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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