Drug interactions
Lurasidone + Thiothixene
Severity: Moderate
Lurasidone and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two antipsychotics together increase the risk of sedation, orthostatic hypotension, extrapyramidal symptoms and neuroleptic malignant syndrome. Combined dopamine blockade is additive without clear added benefit, and QT effects may also add.
What this interaction means in plain words
Lurasidone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 antagonism and CNS depressant effects.
What to do
Avoid antipsychotic polypharmacy where possible; if used, monitor for extrapyramidal symptoms, sedation, hypotension and hyperthermia. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Thiothixene?
MediHelp rates the interaction as moderate. Lurasidone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two antipsychotics together increase the risk of sedation, orthostatic hypotension, extrapyramidal symptoms and neuroleptic malignant syndrome. Combined dopamine blockade is additive without clear added benefit, and QT effects may also add.
How serious is the interaction between Lurasidone and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible; if used, monitor for extrapyramidal symptoms, sedation, hypotension and hyperthermia. Use the lowest effective doses.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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