Drug interactions
Lurasidone + Tiagabine
Severity: Moderate
Lurasidone and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine can cause dizziness, somnolence and impaired concentration, which may be increased by lurasidone. Antipsychotics may also lower the seizure threshold, potentially reducing the antiepileptic effect of tiagabine.
What this interaction means in plain words
Lurasidone and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; antipsychotic lowering of seizure threshold may oppose anticonvulsant action.
What to do
Monitor sedation and seizure frequency after starting or changing doses. Adjust tiagabine dose if seizure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Tiagabine?
MediHelp rates the interaction as moderate. Lurasidone and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine can cause dizziness, somnolence and impaired concentration, which may be increased by lurasidone. Antipsychotics may also lower the seizure threshold, potentially reducing the antiepileptic effect of tiagabine.
How serious is the interaction between Lurasidone and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure frequency after starting or changing doses. Adjust tiagabine dose if seizure control worsens.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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