Drug interactions
Lurasidone + Topiramate
Severity: Moderate
Lurasidone and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and cognitive slowing, so combined use may increase CNS depression. Both can also lower the seizure threshold or affect cognition in susceptible patients, and topiramate may cause weight changes.
What this interaction means in plain words
Lurasidone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depressant effects.
What to do
Monitor for excessive sedation, cognitive impairment and psychomotor slowing, and counsel on driving and hazardous tasks. Titrate doses slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lurasidone and Topiramate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Lurasidone with Topiramate?
MediHelp rates the interaction as moderate. Lurasidone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and cognitive slowing, so combined use may increase CNS depression. Both can also lower the seizure threshold or affect cognition in susceptible patients, and topiramate may cause weight changes.
How serious is the interaction between Lurasidone and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, cognitive impairment and psychomotor slowing, and counsel on driving and hazardous tasks. Titrate doses slowly.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
