Drug interactions
Lurasidone + Trifluoperazine
Severity: Moderate
Lurasidone and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases the risk of sedation, orthostatic hypotension, extrapyramidal symptoms and neuroleptic malignant syndrome. Trifluoperazine is a high-potency phenothiazine, so additive dopamine blockade is notable.
What this interaction means in plain words
Lurasidone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor antagonism and CNS depressant effects.
What to do
Avoid concurrent antipsychotics when feasible; if combined, monitor for extrapyramidal symptoms, sedation, hypotension and QT-related symptoms. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Trifluoperazine?
MediHelp rates the interaction as moderate. Lurasidone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases the risk of sedation, orthostatic hypotension, extrapyramidal symptoms and neuroleptic malignant syndrome. Trifluoperazine is a high-potency phenothiazine, so additive dopamine blockade is notable.
How serious is the interaction between Lurasidone and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent antipsychotics when feasible; if combined, monitor for extrapyramidal symptoms, sedation, hypotension and QT-related symptoms. Use the lowest effective doses.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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