Drug interactions
Lurasidone + Triprolidine
Severity: Moderate
Lurasidone and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause somnolence and akathisia, and triprolidine may add to the sedative effect. Patients may notice reduced alertness and impaired performance of skilled tasks.
What this interaction means in plain words
Lurasidone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive sedation and advise caution with driving. A non-sedating antihistamine is preferable if treatment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Triprolidine?
MediHelp rates the interaction as moderate. Lurasidone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause somnolence and akathisia, and triprolidine may add to the sedative effect. Patients may notice reduced alertness and impaired performance of skilled tasks.
How serious is the interaction between Lurasidone and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise caution with driving. A non-sedating antihistamine is preferable if treatment is needed.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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