Drug interactions
Lurasidone + Venlafaxine
Severity: Moderate
Lurasidone and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is used with antidepressants, but combination with venlafaxine may rarely cause serotonin syndrome or neuroleptic malignant syndrome. Additive sedation and dizziness may also occur.
What this interaction means in plain words
Lurasidone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic pharmacodynamic effects and additive CNS depression.
What to do
Monitor for signs of serotonin toxicity, neuroleptic malignant syndrome and excess sedation, especially during initiation and dose increases. Adjust doses if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Venlafaxine?
MediHelp rates the interaction as moderate. Lurasidone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is used with antidepressants, but combination with venlafaxine may rarely cause serotonin syndrome or neuroleptic malignant syndrome. Additive sedation and dizziness may also occur.
How serious is the interaction between Lurasidone and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity, neuroleptic malignant syndrome and excess sedation, especially during initiation and dose increases. Adjust doses if adverse effects emerge.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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